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| annaCob | Дата: Суббота, 2015-01-24, 1:19 AM | Сообщение # 198 |
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| MauriceIgDrx | Дата: Четверг, 2015-01-29, 9:59 PM | Сообщение # 199 |
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| mnakiend | Дата: Вторник, 2015-03-17, 6:29 AM | Сообщение # 202 |
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| mnakiend | Дата: Среда, 2015-03-18, 1:22 AM | Сообщение # 203 |
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| Cliyerug | Дата: Суббота, 2015-03-21, 2:48 PM | Сообщение # 204 |
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| famuyiyaoj | Дата: Четверг, 2015-04-09, 9:31 PM | Сообщение # 205 |
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Группа: Гости
| Varenicline (swop name Chantix in the USA and Champix in Canada, Europe and other countries, marketed next to Pfizer, generally speaking in the shape of varenicline tartrate), is a prescription medication habituated to to consider nicotine addiction. Varenicline is a nicotinic receptor unfair agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this respect it is comparable tocytisine and different from the nicotinic enemy, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a fond of agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Inclusive of these mechanisms it can assist some patients to quit smoking.
Medical uses
Varenicline is indicated payment smoking cessation. In a 2006 randomized controlled hearing sponsored through Pfizer, after only year the rate of non-stop abstinence was 10% in the interest placebo, 15% an eye to bupropion and 23% for varenicline.[1 - In a 2009 meta-analysis of 101 studies funded near Pfizer, varenicline was found to be more effectual than bupropion (odds correlation 1.40) and NRTs (odds ratio 1.56).[2 -
A Cochrane systematic review concluded that varenicline improved the distinct possibility of successfully quitting smoking by means of two- to three-fold proportionate to pharmacologically unassisted attempts. Varenicline was more productive than bupropion in this view but not statistically superior to NRT.[3 -
The FDA has approved the use of varenicline in requital for up to twelve weeks. If smoking cessation has been achieved it may be continued after another twelve weeks.[4 -
Varenicline has not been tested in those junior to 18 years prehistoric or pregnant women and that being so is not recommended for use at near these groups.
Adverse effects
Nausea occurs commonly in people winning varenicline. Other less worn out side effects subsume cephalalgia, painfulness sleeping, and psych jargon exceptional dreams. Rare side effects reported sooner than people winning varenicline compared to placebo include variation in taste, vomiting,abdominal pain, flatulence, and constipation. In a recent meta-analysis ownership papers past Leung et al., it has been estimated that instead of every five subjects bewitching varenicline at sustentation doses (1 mg twice daily), there resolution be an experience of nausea, and for every 24 and 35 treated subjects, there will be an conclusion of constipation and flatulence respectively. Gastrointestinal side-effects are signal factors compromising the compliance of varenicline.[5 - [6 -
Sadness and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline as a service to smoking cessation had knowledgeable very many pensive side-effects, including suicidal ideation and occasional suicidal behavior, weird behavior, and drowsiness. On February 1, 2008 the FDA issued an heedful to then again clear its findings, noting that "it appears increasingly like as not that there is an intimacy between Chantix and not joking neuropsychiatric symptoms". It is unexplored whether the psychiatric symptoms are linked to the drug or to nicotine withdrawal symptoms,[citation needed - although not all patients had stopped smoking. The FDA also recommended that healthiness misery professionals and patients notice fitted behavioral and eager changes.[7 - In May 2008, Pfizer updated the shelter news associated with varenicline, noting that "some patients get reported changes in behavior, agitation, depressed feeling ready, suicidal thoughts or actions."[8 -
As of July 1, 2009, the US Edibles and Narcotic Dispensation requires Chantix (varenicline) to effect a swart package trap foretoken, the intermediation's strongest safeness notice, precisely to viewable reports of side effects including concavity, suicidal thoughts, and suicidal actions.[9 -
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